COVID & HIT
Edward Itelman
21/11/2020
- General Analysis
- Demographic and clinical features
- Hospitalization Outcomes
- Outcomes in patients with HIT vs all cohort - HIT status known
- OR On Device
- Outcomes in patients with HIT vs all cohort - HIT status unknown
- Outcomes in DIC patients
- Outcomes in patients with HIT vs patients with Thrombocytopenia without HIT
- Thrombocytopenia laboratory data
- Thrombocytopenia Complications
- Survival Analysis
- Multivariate Analysis
- Analysis of intubated patients
- Boxplot of platlet status
General Analysis
Demographic and clinical features
| Overall | No Thrombocytopenia | Thrombocytopenia | p | Missing | |
|---|---|---|---|---|---|
| n | 107 | 50 | 57 | ||
| Age (median [IQR]) | 64.00 [54.00, 71.50] | 67.50 [53.50, 73.00] | 61.00 [54.00, 68.00] | 0.158 | 0.0 |
| Gender = Female (%) | 20 (18.9) | 14 (28.6) | 6 (10.5) | 0.034 | 0.9 |
| BMI (median [IQR]) | 28.50 [25.40, 31.00] | 29.40 [26.25, 33.62] | 27.90 [24.80, 30.00] | 0.113 | 35.5 |
| Diabetes = 1 (%) | 41 (38.3) | 22 (44.0) | 19 (33.3) | 0.351 | 0.0 |
| IHD = 1 (%) | 18 (16.8) | 10 (20.0) | 8 (14.0) | 0.573 | 0.0 |
| malignancy = 1 (%) | 8 ( 7.5) | 4 ( 8.0) | 4 ( 7.0) | 1.000 | 0.0 |
| Hematological.dx = 1 (%) | 7 ( 6.5) | 3 ( 6.0) | 4 ( 7.0) | 1.000 | 0.0 |
| HTN = 1 (%) | 49 (45.8) | 22 (44.0) | 27 (47.4) | 0.877 | 0.0 |
| Dyslipidemia = 1 (%) | 48 (44.9) | 27 (54.0) | 21 (36.8) | 0.113 | 0.0 |
| COPD.CLD = 1 (%) | 10 ( 9.3) | 6 (12.0) | 4 ( 7.0) | 0.582 | 0.0 |
| CRF = 1 (%) | 12 (11.2) | 3 ( 6.0) | 9 (15.8) | 0.196 | 0.0 |
| thyroid.disease = 1 (%) | 12 (11.2) | 9 (18.0) | 3 ( 5.3) | 0.076 | 0.0 |
Hospitalization Outcomes
| Overall | No Thrombocytopenia | Thrombocytopenia | p | Missing | |
|---|---|---|---|---|---|
| n | 107 | 50 | 57 | ||
| Intubated = 1 (%) | 85 (79.4) | 35 (70.0) | 50 (87.7) | 0.043 | 0.0 |
| Thrombosis = 1 (%) | 12 (11.2) | 4 ( 8.0) | 8 (14.0) | 0.496 | 0.0 |
| DIC = 1 (%) | 16 (15.0) | 1 ( 2.0) | 15 (26.3) | 0.001 | 0.0 |
| Blood.products.needed = 1 (%) | 62 (57.9) | 21 (42.0) | 41 (71.9) | 0.003 | 0.0 |
| PLT.transfusion.needed. = 1 (%) | 13 (12.1) | 0 ( 0.0) | 13 (22.8) | 0.001 | 0.0 |
| FFP = 1 (%) | 15 (14.0) | 2 ( 4.0) | 13 (22.8) | 0.012 | 0.0 |
| Cryo = 1 (%) | 7 ( 6.5) | 0 ( 0.0) | 7 (12.3) | 0.030 | 0.0 |
| INR.prolonged = 1 (%) | 81 (75.7) | 32 (64.0) | 49 (86.0) | 0.016 | 0.0 |
| Device = 1 (%) | 39 (36.4) | 6 (12.0) | 33 (57.9) | <0.001 | 0.0 |
| Ecmo = 1 (%) | 22 (20.6) | 0 ( 0.0) | 22 (38.6) | <0.001 | 0.0 |
| CVVH = 1 (%) | 31 (29.0) | 6 (12.0) | 25 (43.9) | 0.001 | 0.0 |
| Dialysis = 1 (%) | 10 ( 9.3) | 2 ( 4.0) | 8 (14.0) | 0.148 | 0.0 |
| bleeding = 1 (%) | 48 (44.9) | 19 (38.0) | 29 (50.9) | 0.254 | 0.0 |
| Hospitalized.days (median [IQR]) | 22.00 [12.00, 38.50] | 19.00 [9.50, 37.25] | 28.00 [17.00, 39.00] | 0.074 | 0.0 |
| Outcome_factor = Discharge (%) | 59 (55.1) | 34 (68.0) | 25 (43.9) | 0.021 | 0.0 |
| Death = 1 (%) | 48 (44.9) | 16 (32.0) | 32 (56.1) | 0.021 | 0.0 |
Outcomes in patients with HIT vs all cohort - HIT status known
| Overall | 0 | 1 | p | Missing | |
|---|---|---|---|---|---|
| n | 34 | 18 | 16 | ||
| Intubated = 1 (%) | 34 (100.0) | 18 (100.0) | 16 (100.0) | NA | 0.0 |
| Thrombosis = 1 (%) | 6 ( 17.6) | 3 ( 16.7) | 3 ( 18.8) | 1.000 | 0.0 |
| DIC = 1 (%) | 11 ( 32.4) | 7 ( 38.9) | 4 ( 25.0) | 0.619 | 0.0 |
| Blood.products.needed = 1 (%) | 33 ( 97.1) | 17 ( 94.4) | 16 (100.0) | 1.000 | 0.0 |
| PLT.transfusion.needed. = 1 (%) | 11 ( 32.4) | 2 ( 11.1) | 9 ( 56.2) | 0.015 | 0.0 |
| FFP = 1 (%) | 9 ( 26.5) | 4 ( 22.2) | 5 ( 31.2) | 0.837 | 0.0 |
| Cryo = 1 (%) | 6 ( 17.6) | 3 ( 16.7) | 3 ( 18.8) | 1.000 | 0.0 |
| INR.prolonged = 1 (%) | 29 ( 85.3) | 15 ( 83.3) | 14 ( 87.5) | 1.000 | 0.0 |
| Device = 1 (%) | 25 ( 73.5) | 9 ( 50.0) | 16 (100.0) | 0.004 | 0.0 |
| Ecmo = 1 (%) | 18 ( 52.9) | 4 ( 22.2) | 14 ( 87.5) | 0.001 | 0.0 |
| CVVH = 1 (%) | 17 ( 50.0) | 8 ( 44.4) | 9 ( 56.2) | 0.731 | 0.0 |
| Dialysis = 1 (%) | 6 ( 17.6) | 2 ( 11.1) | 4 ( 25.0) | 0.542 | 0.0 |
| bleeding = 1 (%) | 24 ( 70.6) | 12 ( 66.7) | 12 ( 75.0) | 0.877 | 0.0 |
| Hospitalized.days (median [IQR]) | 35.50 [22.00, 45.00] | 41.50 [23.75, 45.00] | 31.50 [21.25, 53.25] | 0.863 | 0.0 |
| Outcome_factor = Discharge (%) | 15 ( 44.1) | 10 ( 55.6) | 5 ( 31.2) | 0.281 | 0.0 |
| Death = 1 (%) | 19 ( 55.9) | 8 ( 44.4) | 11 ( 68.8) | 0.281 | 0.0 |
OR On Device
| exp(coef) [confint] | p | |
|---|---|---|
| (Intercept) | 3.60 [1.44, 10.90] | 0.011 |
| HIT | 0.61 [0.14, 2.66] | 0.505 |
Outcomes in patients with HIT vs all cohort - HIT status unknown
| Overall | 0 | 1 | p | Missing | |
|---|---|---|---|---|---|
| n | 107 | 91 | 16 | ||
| Intubated = 1 (%) | 85 (79.4) | 69 (75.8) | 16 (100.0) | 0.061 | 0.0 |
| Thrombosis = 1 (%) | 12 (11.2) | 9 ( 9.9) | 3 ( 18.8) | 0.544 | 0.0 |
| DIC = 1 (%) | 16 (15.0) | 12 (13.2) | 4 ( 25.0) | 0.400 | 0.0 |
| Blood.products.needed = 1 (%) | 62 (57.9) | 46 (50.5) | 16 (100.0) | 0.001 | 0.0 |
| PLT.transfusion.needed. = 1 (%) | 13 (12.1) | 4 ( 4.4) | 9 ( 56.2) | <0.001 | 0.0 |
| FFP = 1 (%) | 15 (14.0) | 10 (11.0) | 5 ( 31.2) | 0.078 | 0.0 |
| Cryo = 1 (%) | 7 ( 6.5) | 4 ( 4.4) | 3 ( 18.8) | 0.111 | 0.0 |
| INR.prolonged = 1 (%) | 81 (75.7) | 67 (73.6) | 14 ( 87.5) | 0.380 | 0.0 |
| Device = 1 (%) | 39 (36.4) | 23 (25.3) | 16 (100.0) | <0.001 | 0.0 |
| Ecmo = 1 (%) | 22 (20.6) | 8 ( 8.8) | 14 ( 87.5) | <0.001 | 0.0 |
| CVVH = 1 (%) | 31 (29.0) | 22 (24.2) | 9 ( 56.2) | 0.021 | 0.0 |
| Dialysis = 1 (%) | 10 ( 9.3) | 6 ( 6.6) | 4 ( 25.0) | 0.062 | 0.0 |
| bleeding = 1 (%) | 48 (44.9) | 36 (39.6) | 12 ( 75.0) | 0.018 | 0.0 |
| Hospitalized.days (median [IQR]) | 22.00 [12.00, 38.50] | 21.00 [12.00, 37.50] | 31.50 [21.25, 53.25] | 0.026 | 0.0 |
| Outcome_factor = Discharge (%) | 59 (55.1) | 54 (59.3) | 5 ( 31.2) | 0.070 | 0.0 |
| Death = 1 (%) | 48 (44.9) | 37 (40.7) | 11 ( 68.8) | 0.070 | 0.0 |
Outcomes in DIC patients
| Overall | 0 | 1 | p | Missing | |
|---|---|---|---|---|---|
| n | 107 | 91 | 16 | ||
| Intubated = 1 (%) | 85 (79.4) | 69 (75.8) | 16 (100.0) | 0.061 | 0.0 |
| Thrombosis = 1 (%) | 12 (11.2) | 10 (11.0) | 2 ( 12.5) | 1.000 | 0.0 |
| DIC = 1 (%) | 16 (15.0) | 0 ( 0.0) | 16 (100.0) | <0.001 | 0.0 |
| Blood.products.needed = 1 (%) | 62 (57.9) | 47 (51.6) | 15 ( 93.8) | 0.004 | 0.0 |
| PLT.transfusion.needed. = 1 (%) | 13 (12.1) | 6 ( 6.6) | 7 ( 43.8) | <0.001 | 0.0 |
| FFP = 1 (%) | 15 (14.0) | 8 ( 8.8) | 7 ( 43.8) | 0.001 | 0.0 |
| Cryo = 1 (%) | 7 ( 6.5) | 1 ( 1.1) | 6 ( 37.5) | <0.001 | 0.0 |
| INR.prolonged = 1 (%) | 81 (75.7) | 66 (72.5) | 15 ( 93.8) | 0.131 | 0.0 |
| Device = 1 (%) | 39 (36.4) | 26 (28.6) | 13 ( 81.2) | <0.001 | 0.0 |
| Ecmo = 1 (%) | 22 (20.6) | 12 (13.2) | 10 ( 62.5) | <0.001 | 0.0 |
| CVVH = 1 (%) | 31 (29.0) | 21 (23.1) | 10 ( 62.5) | 0.004 | 0.0 |
| Dialysis = 1 (%) | 10 ( 9.3) | 10 (11.0) | 0 ( 0.0) | 0.354 | 0.0 |
| bleeding = 1 (%) | 48 (44.9) | 36 (39.6) | 12 ( 75.0) | 0.018 | 0.0 |
| Hospitalized.days (median [IQR]) | 22.00 [12.00, 38.50] | 22.00 [12.00, 36.50] | 35.50 [18.75, 41.50] | 0.163 | 0.0 |
| Outcome_factor = Discharge (%) | 59 (55.1) | 52 (57.1) | 7 ( 43.8) | 0.471 | 0.0 |
| Death = 1 (%) | 48 (44.9) | 39 (42.9) | 9 ( 56.2) | 0.471 | 0.0 |
Outcomes in patients with HIT vs patients with Thrombocytopenia without HIT
*only includes patients with hit or Thrombocytopenia only
| Overall | 0 | 1 | p | Missing | |
|---|---|---|---|---|---|
| n | 28 | 12 | 16 | ||
| Intubated = 1 (%) | 28 (100.0) | 12 (100.0) | 16 (100.0) | NA | 0.0 |
| Thrombosis = 1 (%) | 5 ( 17.9) | 2 ( 16.7) | 3 ( 18.8) | 1.000 | 0.0 |
| DIC = 1 (%) | 10 ( 35.7) | 6 ( 50.0) | 4 ( 25.0) | 0.333 | 0.0 |
| Blood.products.needed = 1 (%) | 27 ( 96.4) | 11 ( 91.7) | 16 (100.0) | 0.883 | 0.0 |
| PLT.transfusion.needed. = 1 (%) | 11 ( 39.3) | 2 ( 16.7) | 9 ( 56.2) | 0.083 | 0.0 |
| FFP = 1 (%) | 9 ( 32.1) | 4 ( 33.3) | 5 ( 31.2) | 1.000 | 0.0 |
| Cryo = 1 (%) | 6 ( 21.4) | 3 ( 25.0) | 3 ( 18.8) | 1.000 | 0.0 |
| INR.prolonged = 1 (%) | 24 ( 85.7) | 10 ( 83.3) | 14 ( 87.5) | 1.000 | 0.0 |
| Device = 1 (%) | 25 ( 89.3) | 9 ( 75.0) | 16 (100.0) | 0.134 | 0.0 |
| Ecmo = 1 (%) | 18 ( 64.3) | 4 ( 33.3) | 14 ( 87.5) | 0.010 | 0.0 |
| CVVH = 1 (%) | 17 ( 60.7) | 8 ( 66.7) | 9 ( 56.2) | 0.867 | 0.0 |
| Dialysis = 1 (%) | 6 ( 21.4) | 2 ( 16.7) | 4 ( 25.0) | 0.947 | 0.0 |
| bleeding = 1 (%) | 21 ( 75.0) | 9 ( 75.0) | 12 ( 75.0) | 1.000 | 0.0 |
| Hospitalized.days (median [IQR]) | 35.50 [22.00, 45.00] | 41.50 [27.25, 43.50] | 31.50 [21.25, 53.25] | 0.763 | 0.0 |
| Outcome_factor = Discharge (%) | 11 ( 39.3) | 6 ( 50.0) | 5 ( 31.2) | 0.539 | 0.0 |
| Death = 1 (%) | 17 ( 60.7) | 6 ( 50.0) | 11 ( 68.8) | 0.539 | 0.0 |
Thrombocytopenia laboratory data
| Overall | No Thrombocytopenia | Thrombocytopenia | p | Missing | |
|---|---|---|---|---|---|
| n | 107 | 50 | 57 | ||
| TAG (median [IQR]) | 243.00 [139.00, 412.00] | 180.00 [113.50, 369.50] | 310.00 [169.00, 480.00] | 0.042 | 22.4 |
| LDL (median [IQR]) | 119.00 [75.00, 166.00] | 99.00 [69.50, 144.00] | 129.00 [78.00, 168.50] | 0.154 | 28.0 |
| Cre.peak (median [IQR]) | 1.29 [0.92, 3.22] | 1.06 [0.90, 2.11] | 1.81 [1.00, 3.45] | 0.024 | 0.0 |
| PF4 (median [IQR]) | 0.91 [0.61, 1.22] | 0.76 [0.32, 0.76] | 1.03 [0.70, 1.23] | 0.067 | 69.2 |
| Fibrinogen.Nadir (median [IQR]) | 794.00 [678.00, 895.50] | 824.50 [723.75, 913.75] | 747.00 [541.00, 886.00] | 0.021 | 0.0 |
| Fibrinogen.peak (median [IQR]) | 794.00 [678.00, 895.50] | 824.50 [723.75, 913.75] | 747.00 [541.00, 886.00] | 0.021 | 0.0 |
| LDH.PEAK (median [IQR]) | 726.00 [569.00, 1026.50] | 631.50 [514.75, 753.25] | 915.00 [690.00, 1333.00] | <0.001 | 0.0 |
| CRP.Peak (median [IQR]) | 312.00 [230.50, 379.00] | 307.00 [233.08, 398.18] | 317.22 [228.00, 357.00] | 0.888 | 0.0 |
| Ddimer.admission (median [IQR]) | 1508.00 [699.50, 3366.00] | 1273.50 [676.00, 3334.25] | 1594.00 [770.00, 3073.00] | 0.454 | 0.0 |
| Ddimer.nadir (median [IQR]) | 850.00 [475.00, 1251.00] | 819.50 [432.00, 1201.75] | 937.00 [519.00, 1338.00] | 0.341 | 0.0 |
| Ddimer.peak (median [IQR]) | 8229.00 [4304.00, 28365.00] | 5880.50 [2061.50, 16004.00] | 20350.00 [6490.00, 32278.00] | 0.001 | 0.0 |
| HGB.admission (median [IQR]) | 13.09 [11.94, 14.40] | 12.71 [11.88, 13.60] | 13.43 [12.00, 14.54] | 0.073 | 0.0 |
| INR.longest (median [IQR]) | 1.40 [1.27, 1.60] | 1.37 [1.24, 1.48] | 1.50 [1.35, 1.70] | 0.007 | 0.0 |
Thrombocytopenia Complications
| Overall | No Thrombocytopenia | Thrombocytopenia | p | Missing | |
|---|---|---|---|---|---|
| n | 107 | 50 | 57 | ||
| HIT = 1 (%) | 16 (47.1) | 0 ( 0.0) | 16 (57.1) | 0.036 | 68.2 |
| Intubated = 1 (%) | 85 (79.4) | 35 (70.0) | 50 (87.7) | 0.043 | 0.0 |
| PLT.Admission (median [IQR]) | 192.00 [143.50, 271.50] | 239.00 [195.25, 307.75] | 150.00 [124.00, 193.00] | <0.001 | 0.0 |
| PLT.Peak (median [IQR]) | 375.00 [271.50, 475.00] | 462.00 [381.50, 557.00] | 279.00 [240.00, 369.00] | <0.001 | 0.0 |
| Plt.Nadir (median [IQR]) | 131.00 [73.00, 196.50] | 204.00 [175.00, 246.00] | 73.00 [53.00, 99.00] | <0.001 | 0.0 |
| Thrombosis = 1 (%) | 12 (11.2) | 4 ( 8.0) | 8 (14.0) | 0.496 | 0.0 |
| Fibrinogen.Nadir (median [IQR]) | 794.00 [678.00, 895.50] | 824.50 [723.75, 913.75] | 747.00 [541.00, 886.00] | 0.021 | 0.0 |
| DIC = 1 (%) | 16 (15.0) | 1 ( 2.0) | 15 (26.3) | 0.001 | 0.0 |
| Blood.products.needed = 1 (%) | 62 (57.9) | 21 (42.0) | 41 (71.9) | 0.003 | 0.0 |
| PLT.transfusion.needed. = 1 (%) | 13 (12.1) | 0 ( 0.0) | 13 (22.8) | 0.001 | 0.0 |
| FFP = 1 (%) | 15 (14.0) | 2 ( 4.0) | 13 (22.8) | 0.012 | 0.0 |
| Cryo = 1 (%) | 7 ( 6.5) | 0 ( 0.0) | 7 (12.3) | 0.030 | 0.0 |
| Device = 1 (%) | 39 (36.4) | 6 (12.0) | 33 (57.9) | <0.001 | 0.0 |
| Ecmo = 1 (%) | 22 (20.6) | 0 ( 0.0) | 22 (38.6) | <0.001 | 0.0 |
| type (%) | NaN | 79.4 | |||
| VA | 2 ( 9.1) | 0 ( NaN) | 2 ( 9.1) | ||
| VA / VAV / VV | 1 ( 4.5) | 0 ( NaN) | 1 ( 4.5) | ||
| VA/VV | 1 ( 4.5) | 0 ( NaN) | 1 ( 4.5) | ||
| VV | 18 (81.8) | 0 ( NaN) | 18 (81.8) | ||
| Dialysis = 1 (%) | 10 ( 9.3) | 2 ( 4.0) | 8 (14.0) | 0.148 | 0.0 |
| bleeding = 1 (%) | 48 (44.9) | 19 (38.0) | 29 (50.9) | 0.254 | 0.0 |
| Days.to.decline.clexane (median [IQR]) | 8.50 [2.00, 13.75] | 7.00 [0.00, 16.00] | 10.00 [3.00, 12.00] | 0.606 | 19.6 |
| Days.to.decline.Heparin (median [IQR]) | 3.00 [0.00, 7.00] | 8.00 [3.50, 14.00] | 2.50 [0.00, 5.00] | 0.102 | 67.3 |
| Days.to.nadir.clexane (median [IQR]) | 13.00 [1.00, 21.00] | 11.00 [0.00, 18.75] | 14.00 [4.00, 21.50] | 0.212 | 9.3 |
| Days.to.nadir.heparin (median [IQR]) | 8.00 [4.00, 16.50] | 9.00 [3.50, 15.50] | 7.50 [4.00, 16.25] | 0.934 | 67.3 |
| days.to.nadir.from.device (median [IQR]) | 7.00 [4.00, 13.00] | 9.00 [6.00, 12.00] | 7.00 [4.00, 13.75] | 0.977 | 72.9 |
| Days.decline.linezilid (mean (SD)) | -5.72 (13.19) | -4.00 (12.18) | -6.82 (14.25) | 0.672 | 83.2 |
| Days.to.nadir.linezolid (mean (SD)) | -0.79 (13.09) | -2.00 (12.52) | -0.08 (13.91) | 0.768 | 82.2 |
| Outcome_factor = Discharge (%) | 59 (55.1) | 34 (68.0) | 25 (43.9) | 0.021 | 0.0 |
| composite_outcome1 = 1 (%) | 85 (79.4) | 35 (70.0) | 50 (87.7) | 0.043 | 0.0 |
| composite_outcome2 = 1 (%) | 74 (69.2) | 30 (60.0) | 44 (77.2) | 0.087 | 0.0 |
| Note: | |||||
| Composite Outcome 1 = Intubation or Ecmo | |||||
| Composite Outcome 2 = Death, DIC, Bleeding or thrombosis |
Survival Analysis
Multivariate Analysis
Without DIC
| exp(coef) [confint] | p | |
|---|---|---|
| (Intercept) | 4.50 [0.34, 86.59] | 0.266 |
| HIT | 3.69 [0.62, 27.45] | 0.165 |
| Thrombocytopenia_FactorThrombocytopenia | 2.09 [0.21, 28.47] | 0.542 |
| daysFromIntubationToOutcome | 0.93 [0.87, 0.98] | 0.016 |
With DIC
Paients with date of intubation/outcome mismatch
| ID | dateOfIntubation | Day.intubated | dateOfDeath | Date.of.outcome | daysFromIntubationToOutcome |
|---|---|---|---|---|---|
data$daysFromIntubationToOutcome
Analysis of intubated patients
Demographic and clinical features
| Overall | No Thrombocytopenia | Thrombocytopenia | p | Missing | |
|---|---|---|---|---|---|
| n | 85 | 35 | 50 | ||
| Age (median [IQR]) | 66.00 [56.00, 72.00] | 70.00 [61.00, 74.50] | 63.50 [55.00, 70.00] | 0.023 | 0.0 |
| Gender = Female (%) | 14 (16.7) | 9 (26.5) | 5 (10.0) | 0.091 | 1.2 |
| BMI (median [IQR]) | 28.05 [25.42, 30.88] | 29.10 [26.20, 32.80] | 27.90 [25.00, 29.95] | 0.281 | 36.5 |
| Diabetes = 1 (%) | 38 (44.7) | 20 (57.1) | 18 (36.0) | 0.088 | 0.0 |
| IHD = 1 (%) | 15 (17.6) | 9 (25.7) | 6 (12.0) | 0.179 | 0.0 |
| malignancy = 1 (%) | 6 ( 7.1) | 4 (11.4) | 2 ( 4.0) | 0.376 | 0.0 |
| Hematological.dx = 1 (%) | 6 ( 7.1) | 3 ( 8.6) | 3 ( 6.0) | 0.980 | 0.0 |
| HTN = 1 (%) | 45 (52.9) | 18 (51.4) | 27 (54.0) | 0.990 | 0.0 |
| Dyslipidemia = 1 (%) | 40 (47.1) | 21 (60.0) | 19 (38.0) | 0.075 | 0.0 |
| COPD.CLD = 1 (%) | 10 (11.8) | 6 (17.1) | 4 ( 8.0) | 0.344 | 0.0 |
| CRF = 1 (%) | 11 (12.9) | 3 ( 8.6) | 8 (16.0) | 0.499 | 0.0 |
| thyroid.disease = 1 (%) | 10 (11.8) | 7 (20.0) | 3 ( 6.0) | 0.103 | 0.0 |
Hospitalization Outcomes
| Overall | No Thrombocytopenia | Thrombocytopenia | p | Missing | |
|---|---|---|---|---|---|
| n | 85 | 35 | 50 | ||
| Intubated = 1 (%) | 85 (100.0) | 35 (100.0) | 50 (100.0) | NA | 0.0 |
| Thrombosis = 1 (%) | 12 ( 14.1) | 4 ( 11.4) | 8 ( 16.0) | 0.780 | 0.0 |
| DIC = 1 (%) | 16 ( 18.8) | 1 ( 2.9) | 15 ( 30.0) | 0.004 | 0.0 |
| Blood.products.needed = 1 (%) | 61 ( 71.8) | 21 ( 60.0) | 40 ( 80.0) | 0.077 | 0.0 |
| PLT.transfusion.needed. = 1 (%) | 13 ( 15.3) | 0 ( 0.0) | 13 ( 26.0) | 0.003 | 0.0 |
| FFP = 1 (%) | 15 ( 17.6) | 2 ( 5.7) | 13 ( 26.0) | 0.034 | 0.0 |
| Cryo = 1 (%) | 7 ( 8.2) | 0 ( 0.0) | 7 ( 14.0) | 0.056 | 0.0 |
| INR.prolonged = 1 (%) | 70 ( 82.4) | 27 ( 77.1) | 43 ( 86.0) | 0.444 | 0.0 |
| Device = 1 (%) | 39 ( 45.9) | 6 ( 17.1) | 33 ( 66.0) | <0.001 | 0.0 |
| Ecmo = 1 (%) | 22 ( 25.9) | 0 ( 0.0) | 22 ( 44.0) | <0.001 | 0.0 |
| CVVH = 1 (%) | 31 ( 36.5) | 6 ( 17.1) | 25 ( 50.0) | 0.004 | 0.0 |
| Dialysis = 1 (%) | 9 ( 10.6) | 2 ( 5.7) | 7 ( 14.0) | 0.388 | 0.0 |
| bleeding = 1 (%) | 45 ( 52.9) | 17 ( 48.6) | 28 ( 56.0) | 0.649 | 0.0 |
| Hospitalized.days (median [IQR]) | 29.00 [18.00, 41.00] | 26.00 [13.50, 41.50] | 30.50 [20.25, 40.75] | 0.406 | 0.0 |
| Outcome_factor = Discharge (%) | 38 ( 44.7) | 20 ( 57.1) | 18 ( 36.0) | 0.088 | 0.0 |
| Death = 1 (%) | 47 ( 55.3) | 15 ( 42.9) | 32 ( 64.0) | 0.088 | 0.0 |
HIT Complications
| Overall | No Thrombocytopenia | Thrombocytopenia | p | Missing | |
|---|---|---|---|---|---|
| n | 85 | 35 | 50 | ||
| HIT = 1 (%) | 16 ( 47.1) | 0 ( 0.0) | 16 ( 57.1) | 0.036 | 60.0 |
| Intubated = 1 (%) | 85 (100.0) | 35 (100.0) | 50 (100.0) | NA | 0.0 |
| PLT.Admission (median [IQR]) | 193.00 [147.00, 303.00] | 261.00 [222.50, 324.50] | 155.50 [124.50, 198.75] | <0.001 | 0.0 |
| PLT.Peak (median [IQR]) | 369.00 [272.00, 498.00] | 490.00 [423.00, 627.50] | 278.50 [246.75, 361.25] | <0.001 | 0.0 |
| Plt.Nadir (median [IQR]) | 110.00 [67.00, 190.00] | 205.00 [175.00, 243.00] | 72.00 [48.00, 89.75] | <0.001 | 0.0 |
| Thrombosis = 1 (%) | 12 ( 14.1) | 4 ( 11.4) | 8 ( 16.0) | 0.780 | 0.0 |
| Fibrinogen.Nadir (mean (SD)) | 806.29 (218.17) | 876.97 (179.01) | 756.82 (230.85) | 0.012 | 0.0 |
| DIC = 1 (%) | 16 ( 18.8) | 1 ( 2.9) | 15 ( 30.0) | 0.004 | 0.0 |
| Blood.products.needed = 1 (%) | 61 ( 71.8) | 21 ( 60.0) | 40 ( 80.0) | 0.077 | 0.0 |
| PLT.transfusion.needed. = 1 (%) | 13 ( 15.3) | 0 ( 0.0) | 13 ( 26.0) | 0.003 | 0.0 |
| FFP = 1 (%) | 15 ( 17.6) | 2 ( 5.7) | 13 ( 26.0) | 0.034 | 0.0 |
| Cryo = 1 (%) | 7 ( 8.2) | 0 ( 0.0) | 7 ( 14.0) | 0.056 | 0.0 |
| Device = 1 (%) | 39 ( 45.9) | 6 ( 17.1) | 33 ( 66.0) | <0.001 | 0.0 |
| Ecmo = 1 (%) | 22 ( 25.9) | 0 ( 0.0) | 22 ( 44.0) | <0.001 | 0.0 |
| type (%) | NaN | 74.1 | |||
| VA | 2 ( 9.1) | 0 ( NaN) | 2 ( 9.1) | ||
| VA / VAV / VV | 1 ( 4.5) | 0 ( NaN) | 1 ( 4.5) | ||
| VA/VV | 1 ( 4.5) | 0 ( NaN) | 1 ( 4.5) | ||
| VV | 18 ( 81.8) | 0 ( NaN) | 18 ( 81.8) | ||
| Dialysis = 1 (%) | 9 ( 10.6) | 2 ( 5.7) | 7 ( 14.0) | 0.388 | 0.0 |
| bleeding = 1 (%) | 45 ( 52.9) | 17 ( 48.6) | 28 ( 56.0) | 0.649 | 0.0 |
| Days.to.decline.clexane (median [IQR]) | 10.00 [4.00, 16.00] | 10.50 [3.75, 18.50] | 10.00 [5.00, 12.75] | 0.686 | 12.9 |
| Days.to.decline.Heparin (median [IQR]) | 3.00 [0.00, 7.00] | 8.00 [3.50, 14.00] | 2.50 [0.00, 5.00] | 0.102 | 58.8 |
| Days.to.nadir.clexane (median [IQR]) | 15.00 [7.00, 22.00] | 16.00 [4.00, 21.00] | 15.00 [7.00, 23.00] | 0.553 | 9.4 |
| Days.to.nadir.heparin (median [IQR]) | 8.00 [4.00, 16.50] | 9.00 [3.50, 15.50] | 7.50 [4.00, 16.25] | 0.934 | 58.8 |
| days.to.nadir.from.device (median [IQR]) | 7.00 [4.00, 13.00] | 9.00 [6.00, 12.00] | 7.00 [4.00, 13.75] | 0.977 | 65.9 |
| Days.decline.linezilid (mean (SD)) | -5.72 (13.19) | -4.00 (12.18) | -6.82 (14.25) | 0.672 | 78.8 |
| Days.to.nadir.linezolid (mean (SD)) | -0.50 (13.41) | -2.00 (12.52) | 0.45 (14.46) | 0.717 | 78.8 |
| Outcome_factor = Discharge (%) | 38 ( 44.7) | 20 ( 57.1) | 18 ( 36.0) | 0.088 | 0.0 |
| composite_outcome1 = 1 (%) | 85 (100.0) | 35 (100.0) | 50 (100.0) | NA | 0.0 |
| composite_outcome2 = 1 (%) | 70 ( 82.4) | 27 ( 77.1) | 43 ( 86.0) | 0.444 | 0.0 |
| Note: | |||||
| Composite Outcome 1 = Intubation or Ecmo | |||||
| Composite Outcome 2 = Death, DIC, Bleeding or thrombosis |
Survival Analysis
Boxplot of platlet status
