14.2 Pros and Cons of BOLD

14.2.1 Advantages

Some advantages include:

1. It’s non-invasive
2. It’s more and more available
3. There’s high spatial and temporal resolution
4. It can visualize entire network brain areas in specific activities.

14.2.2 Disadvantages

Some cons include:

1. We’re measuring neuronal mass activity, not neuronal units.
2. We don’t yet fully understand how circulation in the brain works.
3. It’s difficult to differentiate between excitation and inhibition.
4. Surrounding signals may have physical and biological constraints.